a Record control number 000274634400015

a ISSN 0172-8172

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WE 544

b Item number .T57 2010

a Personal name Soylu, Alper.

h Medium Electronic Document

a Title TLR-2 Arg753Gln, TLR-4 Asp299Gly, and TLR-4 Thr399Ile polymorphisms in Henoch Schonlein purpura with and without renal involvement.

c Statement of responsibility, etc Alper Soylu, Sefa Kızıldağ, Salih Kavukçu, Sultan Cingöz, Mehmet Türkmen, Belde Kasap Demir, Meral Sakızlı.

c Date of publication, distribution, etc 2010.

b Name of publisher, distributor, etc Springer,

a Place of publication, distribution, etc New York :

a Summary, etc Infections may trigger or aggravate glomerulonephritidis and renal vasculitis like Henoch Schonlein purpura (HSP). HSP is seen more frequently in patients with familial Mediterranean fever in which TLR-2 Arg753Gln polymorphism frequency is increased. Although renal involvement is the most important factor affecting the prognosis in HSP, it is not known which patients will have renal disease or why some patients have severe renal involvement while some others have mild renal disease. We investigated the role of TLR-2 and TLR-4 polymorphisms on the incidence and severity of renal involvement in HSP patients. We studied HSP patients with and without nephritis (n = 15 for each group) and healthy controls (n = 100). TLR-2 Arg753Gln and TLR-4 Asp299Gly/Thr399Ile polymorphisms were analyzed with polymerase chain reaction-restriction fragment length polymorphism method. The frequency of TLR-2 Arg753Gln, TLR-4 Asp299Gly, and Thr399Ile polymorphisms in healthy controls were 1, 3, and 2%, respectively. The frequencies of these polymorphisms were not different in HSP patients with or without nephritis compared to healthy controls. TLR-3 Arg753Gln, TLR-4 Asp299Gly, and Thr399Ile polymorphisms are not increased in HSP or HSP nephritis patients.

a Topical term or geographic name as entry element Rheumatology.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Henoch Schonlein purpura

a Main entry heading Rheumatology Internatıonal

g Relationship information MAR 10 2010, Vol 30 Issue 5, p667-670

x International Standard Serial Number 01728172

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1007/s00296-009-1052-y